ARA-290

Description

Compound Overview

ARA-290 is a synthetic linear undecapeptide whose sequence corresponds to the spatial arrangement of residues on the helix B surface of erythropoietin, rather than to a contiguous stretch of the parent protein’s primary sequence. The N-terminal residue is a pyroglutamate formed by intramolecular cyclization of glutamine, which is reflected in the literature synonyms PHBSP and pyroglutamate helix B surface peptide.

In published biochemical literature the peptide is characterized as a ligand for the heteroreceptor complex formed by the erythropoietin receptor (EPOR) and the beta-common receptor subunit CD131, and as non-erythropoietic in the assay systems tested. Peptide Minds supplies ARA-290 as a lyophilized research reagent for in vitro and preclinical laboratory investigation by qualified researchers.

Specifications

Catalog designation	ARA-290
Synonyms	PHBSP; pyroglutamate helix B surface peptide
CAS number	1208243-50-8
PubChem CID	91810664
UNII	9W5677JKDA
Molecular formula	C51H84N16O21
Molecular weight	1257.32 g/mol
Sequence	Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH
One-letter shorthand	UEQLERALNSS (U = pyroglutamate)
Chain length	11 residues, linear, no disulfide bonds
Physical form	Lyophilized white to off-white powder
Quantity per vial	10 mg
Purity	≥99% by HPLC
Identity confirmation	Mass spectrometry (ESI-MS / MALDI-TOF)
Solubility	Water soluble
Storage, lyophilized	−20 °C, protected from light and moisture
Storage, in solution	2–8 °C; avoid repeated freeze-thaw cycles
Documentation	Third-party Certificate of Analysis per lot

Published Literature

The following references are provided for bibliographic purposes only and describe work conducted by independent investigators. They do not characterize this product and do not constitute any representation about its properties or use.

• Brines M, Patel NSA, Villa P, et al. Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. Proc Natl Acad Sci USA. 2008;105(31):10925–10930. doi:10.1073/pnas.0805594105
• Yao M, Domogatskaya A, Ågren N, et al. Cell Transplant. 2021;30:9636897211039739. doi:10.1177/09636897211039739 — isolated primary cell work.
• Liu G, Liang J, Li W, et al. The protective effect of erythropoietin and its novel derived peptides in peripheral nerve injury. Int Immunopharmacol. 2024;138:112452. doi:10.1016/j.intimp.2024.112452 — review of the peptide class.

Handling

Handle as a laboratory chemical of unknown hazard. Use appropriate personal protective equipment and standard laboratory practice. Consult the Safety Data Sheet before use. This material is not sterile-filled for any parenteral application.

For Research Use Only

This product is supplied strictly as a chemical reagent for in vitro laboratory research and is sold only to qualified research professionals and institutions. It is not a drug, food, cosmetic, or dietary supplement. It is not intended for human or veterinary consumption, diagnostic use, or therapeutic use, and it has not been evaluated or approved by the FDA for any use. It is not intended to diagnose, treat, cure, or prevent any condition. Purchaser must be 21 years of age or older and assumes full responsibility for safe handling, storage, regulatory compliance, and disposal.

Frequently Asked Questions

What is ARA-290?

ARA-290 is a synthetic 11-residue linear peptide (CAS 1208243-50-8) whose sequence corresponds to the helix B surface region of erythropoietin. Peptide Minds supplies it as a lyophilized powder for laboratory research use only.

What is the molecular formula and molecular weight of ARA-290?

The molecular formula is C51H84N16O21 and the average molecular weight is 1257.32 g/mol. The sequence is Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH, with an N-terminal pyroglutamate residue.

What receptor does the published literature associate with this peptide?

Published biochemical literature describes ARA-290 as a ligand for the heteroreceptor complex formed by the erythropoietin receptor and the CD131 beta-common receptor subunit. This statement summarizes third-party published work and is not a claim about this product.

What purity grade is supplied and is a COA provided?

Each lot is supplied at ≥99% purity by HPLC and is accompanied by a third-party Certificate of Analysis documenting purity, mass confirmation, and appearance. The COA for the current lot is linked on this page.

How is ARA-290 stored?

Lyophilized material is stored at −20 °C, protected from light and moisture. Material in solution is stored at 2–8 °C, and repeated freeze-thaw cycles are avoided. As a linear peptide with no disulfide bonds, the compound is stable under standard laboratory handling.

What quantity is supplied per vial?

Each vial contains 10 mg of lyophilized ARA-290.

Is ARA-290 approved for human use?

No. ARA-290 is supplied strictly as a research chemical for laboratory use by qualified researchers. It is not a drug, dietary supplement, or consumer product, is not approved by the FDA for any use, and is not intended for human or veterinary consumption.

Who can purchase this product?

Purchases are limited to qualified research professionals, laboratories, and research organizations. Purchasers must be 21 years of age or older and are responsible for compliance with all applicable laws and institutional requirements.