IGF-1 LR3

Description

⚠️ LABORATORY RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL CONSUMPTION
This product is supplied exclusively for in vitro and laboratory research by qualified personnel. It is not approved by the FDA for any clinical, therapeutic, diagnostic, cosmetic, dietary, or veterinary application.

IGF-1 LR3

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is an 83-residue recombinant analog of human IGF-1 with a 13-amino-acid N-terminal extension and an Arg-for-Glu substitution at position 3. These modifications sharply reduce affinity for IGF-binding proteins, giving the analog enhanced and prolonged activity in cell-culture systems. It is a standard reagent in cell-proliferation, receptor-signaling, and growth-factor research. Supplied as a lyophilized powder, 100 mcg per vial.

Product Specifications

Mechanistic Background

Because IGF-1 LR3 binds IGFBPs weakly, a greater fraction of the ligand remains available to engage the IGF-1 receptor in culture, which is why it is widely used as a cell-culture media component and receptor-pharmacology tool.

Research Applications

IGF-1 LR3 is used in in vitro and preclinical model systems to investigate:

• IGF-1 receptor binding, autophosphorylation, and PI3K/Akt and MAPK signaling
• Cell-proliferation, differentiation, and survival assays
• Serum-free and defined cell-culture media supplementation
• Satellite-cell and myoblast culture models
• IGF-binding-protein interaction and displacement studies
• Comparative studies with native IGF-1

Storage & Handling

Store lyophilized material at −20 °C, protected from light and moisture. Allow the vial to reach room temperature before opening. Following reconstitution in a suitable laboratory buffer, store at 2–8 °C and use within the timeframe established by your laboratory’s stability protocols. Avoid repeated freeze–thaw cycles. Handle in accordance with standard laboratory practice for peptide reagents.

Published Literature

1. Francis GL, Ross M, Ballard FJ, et al. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency. J Mol Endocrinol. 1992;8(3):213–223.

Research Use Only Statement

IGF-1 LR3 is a chemical reagent supplied solely for laboratory research and analytical purposes. It is not a drug, dietary supplement, cosmetic, food additive, or medical device, and it has not been evaluated by the U.S. Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease in humans or animals. Peptide Minds is a research chemical supplier and is not a pharmacy, compounding facility, or medical provider. The purchaser is responsible for ensuring the material is handled by trained personnel in accordance with all applicable laws, regulations, and institutional policies.