AOD-9604

Description

⚠️ LABORATORY RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL CONSUMPTION
This product is supplied exclusively for in vitro and laboratory research by qualified personnel. It is not approved by the FDA for any clinical, therapeutic, diagnostic, cosmetic, dietary, or veterinary application.

AOD-9604

AOD-9604 is a synthetic 16-residue peptide corresponding to the C-terminal region (residues 177–191) of the human growth hormone sequence, with an additional N-terminal tyrosine. Because this fragment retains the lipid-metabolism-associated region of the parent protein without the receptor-binding domains responsible for IGF-1 signaling, it is used as a tool compound in lipid metabolism, adipocyte biology, and β-adrenergic signaling research. Supplied as a high-purity lyophilized powder, 5 mg per vial.

Product Specifications

Mechanistic Background

In published preclinical work the 177–191 fragment has been reported to influence β₃-adrenergic receptor expression and downstream lipolytic signaling in adipose tissue, while lacking the IGF-1-inducing activity of the intact hormone. These observations make the fragment a useful comparator for dissecting which regions of the parent protein contribute to specific metabolic signaling events.

Research Applications

AOD-9604 is used in in vitro and preclinical model systems to investigate:

• β₃-adrenergic receptor signaling in adipocyte cultures
• Lipolysis and lipogenesis pathway readouts in adipose tissue models
• Fatty-acid oxidation and mitochondrial activity assays
• Comparative studies against full-length growth hormone and other C-terminal fragments
• Cartilage and chondrocyte biology models
• Peptide stability, degradation, and analytical method development

Storage & Handling

Store lyophilized material at −20 °C, protected from light and moisture. Allow the vial to reach room temperature before opening. Following reconstitution in a suitable laboratory buffer, store at 2–8 °C and use within the timeframe established by your laboratory’s stability protocols. Avoid repeated freeze–thaw cycles. Handle in accordance with standard laboratory practice for peptide reagents.

Published Literature

1. Heffernan M, Summers RJ, Thorburn A, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and β3-AR knock-out mice. Endocrinology. 2001;142(12):5182–5189.
2. Ng FM, Sun J, Sharma L, et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274–278.

Research Use Only Statement

AOD-9604 is a chemical reagent supplied solely for laboratory research and analytical purposes. It is not a drug, dietary supplement, cosmetic, food additive, or medical device, and it has not been evaluated by the U.S. Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease in humans or animals. Peptide Minds is a research chemical supplier and is not a pharmacy, compounding facility, or medical provider. The purchaser is responsible for ensuring the material is handled by trained personnel in accordance with all applicable laws, regulations, and institutional policies.