Description

MT-2 – 10mg

Classification: Synthetic α-MSH (alpha-melanocyte stimulating hormone) analog, melanocortin receptor agonist

What is MT-2?

MT-2 (MT-II) is a synthetic peptide analog of the endogenous melanocortin hormone α-MSH. It was originally developed as a potential therapeutic for skin photoprotection, given its ability to stimulate melanin production. Beyond pigmentation, MT-II has been studied for appetite regulation, sexual function, and energy balance, making it a peptide of multidisciplinary research interest.

Summary Table

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Chemical Structure

🧪 The peptide is a cyclic heptapeptide analog of α-MSH, structurally engineered to enhance receptor affinity and metabolic stability.

Mechanism of Action

MT-2 acts as a non-selective melanocortin receptor agonist with affinity for MC1R, MC3R, MC4R, and MC5R.

• MC1R Activation → Stimulates melanogenesis, leading to increased eumelanin production and darker skin pigmentation.

• MC3R/MC4R Activation → Impacts energy homeostasis, appetite regulation, and sexual behavior.

• MC4R specifically plays a role in libido enhancement and erectile function.

• MC5R influences exocrine gland activity.

This broad receptor activity explains MT-II’s wide-ranging physiological research outcomes.

Research Applications

1. Dermatological Research

• Photoprotection and reduced UV-induced DNA damage

• Investigated as adjunct therapy in conditions like erythropoietic protoporphyria

2. Endocrine & Metabolic Studies

• Appetite suppression and weight regulation via MC4R pathways

• Studied in models of obesity and metabolic syndrome

3. Sexual Medicine Research

• Preclinical and clinical exploration for erectile dysfunction and female sexual arousal disorder

4. Neuroscience & Behavioral Studies

• Investigation into central melanocortin system’s role in reward pathways and mood regulation

Safety & Tolerability

• Commonly Reported in Research Models: Transient nausea, flushing, appetite suppression, and darkening of moles/freckles

• Dose-Dependent Effects: Hyperpigmentation is proportional to dosing

• Long-Term Studies: Limited; further investigation required for chronic use effects

• Storage Note: Must be reconstituted with sterile water and used under controlled laboratory settings only

⚠️ Disclaimer: MT-2 is strictly intended for research purposes only. It is not approved for human consumption, medical use, or cosmetic tanning outside controlled studies.

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