TB-500

Description

⚠️ LABORATORY RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL CONSUMPTION
This product is supplied exclusively for in vitro and laboratory research by qualified personnel. It is not approved by the FDA for any clinical, therapeutic, diagnostic, cosmetic, dietary, or veterinary application.

TB-500

TB-500 is a synthetic 43-residue peptide corresponding to the actin-binding region of thymosin β4, a ubiquitous G-actin-sequestering protein. It is used as a tool compound in actin dynamics, cell-motility, angiogenesis, and extracellular-matrix research in cell-culture and preclinical model systems. Supplied as a lyophilized powder, 10 mg per vial.

Product Specifications

Mechanistic Background

Thymosin β4 binds monomeric actin through its central LKKTET motif, regulating the pool of polymerization-competent actin. The TB-500 fragment retains this motif and is therefore used to probe cytoskeletal reorganization, cell migration, and related signaling in laboratory models.

Research Applications

TB-500 is used in in vitro and preclinical model systems to investigate:

• G-actin sequestration and actin polymerization kinetics
• Endothelial-cell migration and tube-formation (angiogenesis) assays
• Fibroblast and keratinocyte motility in scratch-wound culture models
• Extracellular-matrix organization and MMP expression
• Cardiomyocyte and epithelial cell-culture models of cytoskeletal remodeling
• Comparative studies with full-length thymosin β4 and Ac-SDKP

Storage & Handling

Store lyophilized material at −20 °C, protected from light and moisture. Allow the vial to reach room temperature before opening. Following reconstitution in a suitable laboratory buffer, store at 2–8 °C and use within the timeframe established by your laboratory’s stability protocols. Avoid repeated freeze–thaw cycles. Handle in accordance with standard laboratory practice for peptide reagents.

Published Literature

1. Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37–51.
2. Sosne G, Qiu P, Christopherson PL, Wheater MK. Thymosin beta 4 modulation of corneal and dermal wound healing. Ann N Y Acad Sci. 2010;1194:190–198.

Research Use Only Statement

TB-500 is a chemical reagent supplied solely for laboratory research and analytical purposes. It is not a drug, dietary supplement, cosmetic, food additive, or medical device, and it has not been evaluated by the U.S. Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease in humans or animals. Peptide Minds is a research chemical supplier and is not a pharmacy, compounding facility, or medical provider. The purchaser is responsible for ensuring the material is handled by trained personnel in accordance with all applicable laws, regulations, and institutional policies.