SNAP-8

Description

⚠️ LABORATORY RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL CONSUMPTION
This product is supplied exclusively for in vitro and laboratory research by qualified personnel. It is not approved by the FDA for any clinical, therapeutic, diagnostic, cosmetic, dietary, or veterinary application.

SNAP-8 (Acetyl Octapeptide-3)

SNAP-8 is a synthetic N-acetylated octapeptide modelled on the N-terminal domain of SNAP-25, a core component of the SNARE complex that mediates synaptic-vesicle docking. It is used as a tool compound in SNARE-complex assembly research, neuromuscular signaling models, and in vitro dermatological and cosmeceutical research. Supplied as a lyophilized powder, 10 mg per vial.

Product Specifications

Mechanistic Background

As a SNAP-25 N-terminal mimetic, SNAP-8 competes for a position in the SNARE complex and has been reported to reduce complex formation efficiency in vitro, providing a non-toxic tool for probing vesicle-fusion machinery.

Research Applications

SNAP-8 is used in in vitro and ex vivo model systems to investigate:

• SNARE complex (SNAP-25 / syntaxin / VAMP) assembly and competitive-binding assays
• Vesicle-docking and neurotransmitter-release readouts in cell-culture models
• Comparative studies against acetyl hexapeptide-8 and related SNAP-25 mimetics
• Skin-permeability and topical-delivery models (Franz cell, reconstructed epidermis)
• Fibroblast and keratinocyte culture studies
• Peptide stability and analytical method development

Storage & Handling

Store lyophilized material at −20 °C, protected from light and moisture. Allow the vial to reach room temperature before opening. Following reconstitution in a suitable laboratory buffer, store at 2–8 °C and use within the timeframe established by your laboratory’s stability protocols. Avoid repeated freeze–thaw cycles. Handle in accordance with standard laboratory practice for peptide reagents.

Published Literature

1. Blanes-Mira C, Clemente J, Jodas G, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303–310.
2. Zdrada-Nowak J, Surgiel-Gemza A, Szatkowska M. Acetyl Hexapeptide-8 in Cosmeceuticals — A Review of Skin Permeability and Efficacy. Int J Mol Sci. 2025.

Research Use Only Statement

SNAP-8 (Acetyl Octapeptide-3) is a chemical reagent supplied solely for laboratory research and analytical purposes. It is not a drug, dietary supplement, cosmetic, food additive, or medical device, and it has not been evaluated by the U.S. Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease in humans or animals. Peptide Minds is a research chemical supplier and is not a pharmacy, compounding facility, or medical provider. The purchaser is responsible for ensuring the material is handled by trained personnel in accordance with all applicable laws, regulations, and institutional policies.