SNAP-8
$37.00
10mg of reagent-grade SNAP-8
Third Party Verified
Description
Product Summary – SNAP-8 – Synthetic Cosmetic Neuropeptide
| Field | Details |
| Product Name | SNAP-8 (Acetyl Octapeptide-3) |
| Category | Synthetic cosmetic neuropeptide |
| Length | 8 amino acids (octapeptide). |
| Amino Acid Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ (Ac-EEMQRRAD-NH₂). |
| Molecular Formula | C₄₁H₇₀N₁₆O₁₆S |
| Molecular Weight | ≈ 1075.16 Da |
| Form & Purity | Lyophilized peptide powder for research use; typical vendor spec ≥95% purity by HPLC (confirm COA for each lot). |
| Storage | Store dry at ≤ −18 to −20 °C. Reconstituted solutions: short-term refrigerate (2–8 °C); avoid repeated freeze–thaw. |
| Typical Concentration | No standardized concentration for SNAP-8 in peer-reviewed trials. Product formulations vary; do not assume Argireline concentrations apply to SNAP-8. |
| Key Mechanisms | – SNAP-25 mimetic → competes with endogenous SNAP-25 for SNARE complex binding.
– Disrupts SNARE complex formation → prevents full vesicle docking machinery from assembling. – Cosmetic endpoint → decreased muscle contraction intensity → smoother skin/wrinkle reduction. |
| Research / Clinical Use Cases | Topical cosmeceuticals → dynamic wrinkle reduction
Translational pilot uses → explored for neuromuscular modulation |
| Common AEs / Safety Signals | – Generally well tolerated topically; local irritation possible.
– No systemic toxicity reported at cosmetic formulation exposures. – High-quality long-term safety data are sparse. |
| Contraindications / Warnings | Research / cosmetic use only; not an approved therapeutic. Avoid use on broken/compromised skin in research subjects. |
| Regulatory / Compliance | Marketed as a cosmetic peptide ingredient (INCI naming varies). No approved therapeutic indications. |
Mechanism of Action of SNAP-8
SNAP-8 is a SNAP-25-mimetic competitor modulator of the SNARE complex. SNAP-8 competes the SNAP-25 for binding on the receptor interfaces on the SNARE bundle (syntaxin-1/SNAP-25/VAMPs). Normally, SNAP-25 binds the receptor site to trigger the ACh release from the neuronal end. However, when SNAP-8 binds to the receptor site, it perturbs the full zipping of the SNARE bundle, leading to incomplete assembly of SNARE proteins. This incomplete assembly dampens the synaptic fusion and reduces the ACh release from the cholinergic terminals, causing less facial muscle contraction to fade the wrinkles. [1]
In vitro and biophysical literature says that SNAP-8 modulates the SNARE complex formation and inhibition of transmitter release, causing reduced muscle contraction. These data show that the peripheral neuro-modulatory mechanism reduces the wrinkle softening endpoints.]
However, SNAP-8 results depend on delivery. Multiple reviews found that the standard topical vehicles may not deliver the neuropeptide to the neuromuscular targets effectively, needing some advanced formulations like O/W and W/O/W emulsions. Transdermal approaches such as dissolving microneedles can also be beneficial. [2]
Because AH-8 is hydrophilic and relatively large in size, it struggles to pass through the skin’s lipophilic stratum corneum, which limits its dermal absorption. To overcome this, formulation approaches such as oil-in-water (O/W) and multiple water-in-oil-in-water (W/O/W) emulsions have been tested to improve delivery. However, whether AH-8 can penetrate deeply enough to reach the neuromuscular junction is still unclear. [3]
Tolerability and Safety Considerations of Snap-8
- Well tolerated in human topical use. No serious or widespread adverse effects.
- No skin sensitization or irritation at typical cosmetic concentrations.
- No acute oral toxicity in animal models, even at very high doses.
- Non-genotoxic in standard mutagenicity testing.
- Low cytotoxic risk at relevant exposures; effects only seen at much higher in vitro concentrations.
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Citations
- Yang, Y., Kong, B., Jung, Y., Park, B., Oh, M., Hwang, J., Cho, J. Y., & Kweon, H. (2018). Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor-Derived Peptides for Regulation of Mast Cell Degranulation. Frontiers in Immunology, 9, 725. https://doi.org/10.3389/fimmu.2018.00725
- Zdrada-Nowak, J., Surgiel-Gemza, A., & Szatkowska, M. (2025). Acetyl Hexapeptide-8 in Cosmeceuticals—A Review of Skin Permeability and Efficacy. International Journal of Molecular Sciences, 26(12), 5722. https://doi.org/10.3390/ijms26125722
- Zdrada-Nowak, J., Surgiel-Gemza, A., & Szatkowska, M. (2025). Acetyl Hexapeptide-8 in Cosmeceuticals—A Review of Skin Permeability and Efficacy. International Journal of Molecular Sciences, 26(12), 5722. https://doi.org/10.3390/ijms26125722
Additional information
| Size | 10 MG |
|---|---|
| Quantity | 1 VIAL, 2 VIALS, 5 VIALS, 10 VIALS |
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