Semax

Description

⚠️ LABORATORY RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL CONSUMPTION
This product is supplied exclusively for in vitro and laboratory research by qualified personnel. It is not approved by the FDA for any clinical, therapeutic, diagnostic, cosmetic, dietary, or veterinary application.

Semax

Semax is a synthetic heptapeptide analog of the ACTH(4–10) fragment in which the C-terminus is extended with the Pro-Gly-Pro tripeptide, conferring resistance to enzymatic degradation. It is used in neuroscience research as a tool compound for studying neurotrophin gene expression, melanocortin-related signaling, and neuroprotective pathways in cellular and preclinical models. Supplied as a lyophilized powder, 7 mg per vial.

Product Specifications

Mechanistic Background

Published preclinical studies report that Semax modulates transcription of neurotrophin and neurotrophin-receptor genes and influences gene-expression networks associated with immune, vascular, and ischemia-response pathways in rodent brain tissue.

Research Applications

Semax is used in in vitro and preclinical neuroscience models to investigate:

• BDNF, NGF, and neurotrophin-receptor gene expression in neuronal cultures
• Transcriptomic responses in ischemia-related preclinical models
• Melanocortin-system signaling and receptor pharmacology
• Neuronal survival and oxidative-stress assays
• Peptide proteolysis, stability, and blood–brain-barrier transport models
• Comparative studies with parent ACTH fragments and Pro-Gly-Pro

Storage & Handling

Store lyophilized material at −20 °C, protected from light and moisture. Allow the vial to reach room temperature before opening. Following reconstitution in a suitable laboratory buffer, store at 2–8 °C and use within the timeframe established by your laboratory’s stability protocols. Avoid repeated freeze–thaw cycles. Handle in accordance with standard laboratory practice for peptide reagents.

Published Literature

1. Dmitrieva VG, Povarova OV, Skvortsova VI, et al. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol. 2010;30(1):71–79.
2. Dolotov OV, Karpenko EA, Seredenina TS, et al. Semax, an analogue of adrenocorticotropin (4–10), binds specifically and increases levels of BDNF protein in rat basal forebrain. J Neurochem. 2006;97(Suppl 1):82–86.

Research Use Only Statement

Semax is a chemical reagent supplied solely for laboratory research and analytical purposes. It is not a drug, dietary supplement, cosmetic, food additive, or medical device, and it has not been evaluated by the U.S. Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease in humans or animals. Peptide Minds is a research chemical supplier and is not a pharmacy, compounding facility, or medical provider. The purchaser is responsible for ensuring the material is handled by trained personnel in accordance with all applicable laws, regulations, and institutional policies.