MK-677

Description

⚠️ LABORATORY RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL CONSUMPTION
This product is supplied exclusively for in vitro and laboratory research by qualified personnel. It is not approved by the FDA for any clinical, therapeutic, diagnostic, cosmetic, dietary, or veterinary application.

MK-677 — Ibutamoren Mesylate (Capsule Reagent)

MK-677 (ibutamoren mesylate) is a synthetic, orally-characterized non-peptide spiroindoline compound described in published literature as a potent agonist of the growth hormone secretagogue receptor (GHSR-1a), the receptor later identified as the target of the endogenous ligand ghrelin. It is supplied in pre-measured capsule form for laboratories that require repeatable milligram-scale reagent quantities for receptor-binding, functional-assay, and analytical workflows.

Product Specifications

Product Name	MK-677 (Ibutamoren Mesylate)
Compound	Ibutamoren mesylate — CAS 159752-10-0 (free base CAS 159634-47-6)
Molecular Formula	C₂₈H₄₀N₄O₈S₂ (mesylate salt)
Molecular Weight	624.77 g/mol
Quantity	12.5 mg per capsule; 30 capsules per container
Form	Pre-measured capsule (inert containment vehicle)
Purity	≥98% by HPLC; see third-party COA
Classification	Non-peptide small molecule — research reagent

Research Applications

MK-677 is used in in vitro and preclinical model systems to investigate:

• GHSR-1a receptor binding and functional activation assays
• Ghrelin-mimetic receptor pharmacology and signal-transduction readouts
• Neuroendocrine GH-axis regulation in cell-culture and preclinical models
• Analytical method development, stability, and metabolite characterization

Format & Handling

This reagent is supplied in pre-measured capsule form. The capsule shell serves as an inert containment and metering vehicle for the research material, allowing precise, repeatable quantities to be transferred to laboratory workflows (for example, dissolution or extraction into an appropriate solvent or buffer prior to analysis). The capsule format is a packaging convenience and does not indicate suitability for ingestion or any in vivo use. Store sealed containers in a cool, dry location protected from light; follow standard laboratory handling procedures for chemical reagents.

Published Literature

1. Patchett AA, Nargund RP, Tata JR, et al. Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. Proc Natl Acad Sci USA. 1995;92(15):7001–7005.
2. Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273(5277):974–977.
3. Smith RG. Development of growth hormone secretagogues. Endocr Rev. 2005;26(3):346–360.

Research Use Only Statement

MK-677 (Capsule Reagent) is a chemical reagent supplied solely for laboratory research and analytical purposes. It is not a drug, dietary supplement, cosmetic, food additive, or medical device, and it has not been evaluated by the U.S. Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease in humans or animals. Peptide Minds is a research chemical supplier and is not a pharmacy, compounding facility, or medical provider. The purchaser is responsible for ensuring the material is handled by trained personnel in accordance with all applicable laws, regulations, and institutional requirements, including safe storage, use, and disposal.

Frequently Asked Questions

What is MK-677?

MK-677 (ibutamoren mesylate, CAS 159752-10-0) is a synthetic non-peptide compound characterized in published literature as a growth hormone secretagogue receptor (GHSR-1a) agonist. Peptide Minds supplies it as a pre-measured capsule reagent for laboratory research use only.

What is the molecular formula and weight?

The mesylate salt is C28H40N4O8S2 with a molecular weight of 624.77 g/mol.

Why is this reagent supplied in capsule form?

The capsule shell is an inert containment and metering vehicle that provides repeatable pre-measured quantities for laboratory workflows. The format is a packaging convenience only and does not indicate suitability for ingestion or any in vivo use.

Is a COA provided?

Yes. Each lot is third-party tested and supplied with a Certificate of Analysis documenting identity and purity (≥98% by HPLC).

Is MK-677 approved for human use?

No. MK-677 is supplied strictly as a research chemical for laboratory use by qualified researchers. It is not a drug, dietary supplement, or consumer product, is not approved by the FDA for any use, and is not intended for human or veterinary consumption.