Ipamoreln

Description

⚠️ LABORATORY RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL CONSUMPTION
This product is supplied exclusively for in vitro and laboratory research by qualified personnel. It is not approved by the FDA for any clinical, therapeutic, diagnostic, cosmetic, dietary, or veterinary application.

Ipamoreln

Ipamoreln is a synthetic pentapeptide that acts as a selective agonist of the growth hormone secretagogue receptor (GHS-R1a, the ghrelin receptor). Its selectivity profile — with minimal reported activity on ACTH, cortisol, or prolactin release in preclinical models — makes it a widely used reference ligand for receptor pharmacology, neuroendocrine signaling, and GH/IGF-1 axis research. Supplied as a high-purity lyophilized powder, 5 mg per vial.

Product Specifications

Mechanistic Background

Ipamoreln binds the ghrelin receptor and stimulates pulsatile GH release in preclinical models in a receptor-dependent manner, without the ACTH/cortisol stimulation reported for earlier secretagogue peptides. This selectivity is the primary reason it is used as a reference ligand in GHS-R1a pharmacology.

Research Applications

Ipamoreln is used in in vitro receptor assays and preclinical model systems to investigate:

• GHS-R1a receptor binding, activation, and signaling (calcium mobilization, cAMP readouts)
• Pituitary somatotroph cell-culture models of GH secretion
• Receptor selectivity comparisons against other secretagogue ligands
• GH/IGF-1 axis signaling in endocrinology models
• Bone-formation and osteoblast pathway studies in preclinical systems
• Ghrelin-receptor structural biology and ligand-recognition studies

Storage & Handling

Store lyophilized material at −20 °C, protected from light and moisture. Allow the vial to reach room temperature before opening. Following reconstitution in a suitable laboratory buffer, store at 2–8 °C and use within the timeframe established by your laboratory’s stability protocols. Avoid repeated freeze–thaw cycles. Handle in accordance with standard laboratory practice for peptide reagents.

Published Literature

1. Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552–561.
2. Andersen NB, Malmlöf K, Johansen PB, et al. The growth hormone secretagogue ipamorelin counteracts the glucocorticoid-induced decrease in bone formation of adult rats. Growth Horm IGF Res. 2001;11(5):266–272.
3. Shiimura Y, Kojima M, Sato T. How the ghrelin receptor recognizes the acyl-modified orexigenic hormone. Front Mol Neurosci. 2025;18.

Research Use Only Statement

Ipamoreln is a chemical reagent supplied solely for laboratory research and analytical purposes. It is not a drug, dietary supplement, cosmetic, food additive, or medical device, and it has not been evaluated by the U.S. Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease in humans or animals. Peptide Minds is a research chemical supplier and is not a pharmacy, compounding facility, or medical provider. The purchaser is responsible for ensuring the material is handled by trained personnel in accordance with all applicable laws, regulations, and institutional policies.