IGF-1 LR3
$26.00
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Description
What is IGF-1 LR3?
IGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arg3) is a recombinant peptide analog of human IGF-1, engineered to have a longer half-life and enhanced biological activity. By replacing the third amino acid with arginine (Arg3) and extending its structure, IGF-1 LR3 resists binding to IGF-binding proteins (IGFBPs), increasing its bioavailability. Researchers utilize IGF-1 LR3 for studies in cellular growth, tissue repair, muscle development, and metabolic signaling.
Product Summary – IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1)
| Field | Details |
| Product Name | IGF-1 LR3 (Long Arg³ Insulin-like Growth Factor-1). |
| Category | Synthetic recombinant IGF-1 analog; modified to improve stability and bioavailability. |
| Length | 83 amino acids (13 amino acids longer than native IGF-1). |
| Amino Acid Sequence | Modified IGF-1 sequence with a 13-amino acid N-terminal extension and substitution of Arg for Glu at position 3. |
| Molecular Formula & Weight | C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉; Molecular weight ≈ 9,111 Da. |
| Form & Purity | Lyophilized peptide powder; typical research purity ≥95% (HPLC). |
| Storage | Store dry at −20 °C; protect from light and moisture. Reconstituted solutions should be refrigerated (2–8 °C) and used within days. |
| Key Mechanisms of Action | • Potent agonist at the IGF-1 receptor → stimulates PI3K/Akt and MAPK pathways.
• Promotes protein synthesis, cell survival, and proliferation. • Enhances glucose uptake and insulin-like metabolic effects. • Longer half-life (~20–30 h vs ~12 min native IGF-1) due to reduced binding to IGF binding proteins (IGFBPs). |
| Research / Clinical Use Cases | • Studied in muscle growth and regeneration models (satellite cell activation, myoblast proliferation).
• Neuroprotective and cognitive function research (supports neuronal survival, plasticity). • Investigated in metabolic studies for insulin sensitivity and glucose control. • Wound healing and tissue repair models. |
| Common AEs / Safety Signals | Possible hypoglycemia (insulin-like effect), edema, arthralgia, headache. Risk rises with supraphysiologic dosing. |
| Contraindications / Warnings | Not FDA-approved. Caution in malignancy due to proliferative/anti-apoptotic properties. Research use only. |
| Regulatory / Compliance | Not approved for therapeutic use in major jurisdictions. Prohibited in competitive sports under WADA. |
Chemical Structure
IGF-1 LR3 is a single-chain polypeptide of 83 amino acids. Its modifications (Arg3 substitution and an extended N-terminus) reduce binding to IGFBPs and prolong systemic activity.
Mechanism of Action
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IGF-1 Receptor Activation – IGF-1 LR3 binds to the IGF-1 receptor (IGF-1R), triggering tyrosine kinase signaling.
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PI3K/AKT & MAPK Pathways – Activates intracellular pathways involved in protein synthesis, cell survival, and proliferation.
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Reduced IGFBP Affinity – Structural modifications prevent sequestration by IGFBPs, increasing free peptide availability.
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Metabolic Regulation – Enhances glucose uptake, insulin sensitivity, and lipid metabolism.
Research Applications
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Muscle Biology – Studied for hypertrophy, myoblast proliferation, and satellite cell activation.
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Neuroprotection – Investigated for its role in neuronal survival and repair mechanisms.
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Tissue Regeneration – Applied in studies of wound healing, cartilage repair, and angiogenesis.
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Endocrinology & Metabolism – Used to explore insulin-like effects, glucose regulation, and metabolic pathways.
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Oncology Research – Examined for its influence on tumor progression and resistance mechanisms due to growth factor signaling.
Safety & Tolerability
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Preclinical Findings: IGF-1 LR3 demonstrates potent biological activity but requires strict dosing in experimental settings.
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Adverse Effects: High levels may induce hypoglycemia, edema, or abnormal tissue growth in research models.
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Research Use Only: Not approved for human or veterinary therapeutic use. Handling requires biosafety protocols in compliance with laboratory standards
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Additional information
| SIze | 100 MCG |
|---|---|
| Quantity | 1 VIAL, 2 VIALS, 5 VIALS, 10 VIALS |
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