BPC-157

Description

Product Specifications – BPC-157 (Body Protection Compound-157)

Field	Details
Product Name	BPC-157
Category	Synthetic pentadecapeptide (15 amino acids) derived from gastric protein sequence Investigational peptide for laboratory research
Molecular Formula	C₆₂H₉₈N₁₆O₂₂
Molecular Weight	~1419.5 g/mol
Peptide Length	15 amino acids
Form & Purity	Lyophilized powder; ≥95–98% purity (HPLC-verified)
Storage	Lyophilized: −20°C to −80°C, dry, protected from light Reconstituted: 4°C short-term; avoid repeated freeze-thaw cycles
Compliance Status	Not FDA/EMA approved. Listed as WADA-prohibited substance. Distributed for laboratory research use only.

Amino Acid Sequence of BPC-157

Gly–Glu–Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu–Val

Molecular Pathway Research Applications

BPC-157 is studied in controlled laboratory settings for its interactions with various cellular signaling pathways. Research focuses on molecular mechanisms in in vitro models and preclinical systems.

Angiogenesis & Cytoskeletal Pathway Studies

Laboratory research investigates BPC-157’s effects on VEGFR2 phosphorylation and internalization in endothelial cell cultures. Studies examine:

• VEGFR2 activation pathways and intracellular adaptor protein recruitment
• Focal adhesion kinase (FAK) phosphorylation mechanisms
• Paxillin recruitment and integrin-actin cytoskeleton interactions
• Endothelial cell proliferation and migration assays in vitro

Research models study the combined effects of VEGFR2-mediated proliferation and FAK-paxillin-mediated cellular motility in angiogenesis pathway investigations. [1]

Cell Signaling & Survival Pathway Research

In vitro studies examine BPC-157’s effects on:

• MAPK/ERK1/2 signaling cascade activation in cell culture models
• PI3K-Akt pathway interactions and downstream target phosphorylation
• Apoptosis regulation mechanisms in cellular assays
• Protein synthesis and metabolic activity pathways in tissue culture systems

Laboratory investigations focus on Akt signaling pathway components and their roles in cell survival mechanisms. [2]

Nitric Oxide System & Endothelial Research

Research applications include studies of:

• Endothelial nitric oxide synthase (eNOS) modulation through upstream kinase pathways
• Caveolin-1 (Cav-1) binding interactions with eNOS in cell culture
• Nitric oxide (NO) production mechanisms and microcirculatory effects in vascular models
• Platelet aggregation pathways in coagulation research

Studies examine NO production mechanisms following cav-1 displacement in endothelial cell models and microcirculatory perfusion in preclinical research systems. [3]

Inflammatory Pathway & Cytokine Research

Laboratory models investigate:

• NF-κB transcriptional pathway regulation through kinase modulation
• Cytokine expression studies (TNF-α, IL-1β, IL-6, COX-2) in cell culture
• Inflammatory mediator production in in vitro inflammation models
• Oxidative stress pathway research in cellular systems

Research examines NF-κB activity modulation and its effects on inflammatory mediator transcription in controlled laboratory conditions. [4]

Growth Factor & Gene Expression Studies

Investigational applications include:

• Early growth response gene (EGR-1) expression analysis in cell culture
• IGF-1/GH signaling pathway interactions in cellular models
• Anabolic and mitogenic response pathways in muscle and bone cell cultures
• Matrix metalloproteinase and angiogenic mediator expression studies

Laboratory research focuses on EGR-1-mediated transcriptional control of cell growth and repair genes through matrix and angiogenic mediator pathways. [5]

Extracellular Matrix (ECM) Remodeling Research

Studies examine:

• Matrix metalloproteinase activity and expression in fibroblast cultures
• Fibroblast migration, phenotype switching, and collagen synthesis pathways
• ERK/Akt/FAK signaling interactions with EGR-1-linked transcription
• Collagen organization and deposition mechanisms in tissue culture models
• ECM structural protein research in cellular repair systems

Research investigates collagen organization processes and structural architecture development in controlled laboratory models. [6]

Laboratory Research Focus Areas

BPC-157 is utilized in various controlled research contexts:

• Gastrointestinal Research: Cellular models studying gastric mucosa, intestinal epithelial barriers, and inflammatory bowel disease pathways
• Musculoskeletal Studies: In vitro tendon, ligament, muscle, and bone cell culture research
• Organ System Research: Ischemia-reperfusion models in liver, kidney, and lung tissue studies
• Neuroscience Applications: Central nervous system pathway research in stroke models and traumatic injury systems

Note: All applications represent controlled laboratory research conducted in vitro or in preclinical animal models. Not validated for clinical use.

Laboratory Handling & Safety Considerations

Storage Protocol:

• Store lyophilized powder at −20°C to −80°C in dry conditions protected from light
• Reconstitute using appropriate sterile technique
• Store reconstituted solutions at 4°C for short-term use
• Avoid repeated freeze-thaw cycles to maintain peptide integrity
• Create aliquots for single-use to preserve stability

Research Observations from Literature:

Published studies in animal research models report general tolerability with no major systemic toxicity observations in preclinical investigations. Some research models note mild observations including gastrointestinal effects in certain experimental protocols. Current experimental datasets from animal studies do not show tumor-promoting effects in laboratory conditions, though theoretical considerations regarding angiogenesis pathway modulation exist in research literature.

Important: These represent findings from controlled animal research studies and limited experimental reports. Not indicative of human safety profiles. Large-scale controlled human trials are not available.

Research References

⚠️ CITATION NOTICE: The following references represent published scientific research conducted in controlled laboratory and preclinical settings. These studies do not represent approved clinical applications and are provided for research reference purposes only.

1. Hsieh, M. J., Liu, H. T., Wang, C. N., Huang, H. Y., Lin, Y., Ko, Y. S., Wang, J. S., Chang, V. H., & Pang, J. S. (2017). Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. Journal of Molecular Medicine (Berlin, Germany), 95(3), 323–333. https://doi.org/10.1007/s00109-016-1488-y
2. Vukojevic, J., Milavić, M., Perović, D., Ilić, S., Čilić, A. Z., Đuran, N., Štrbe, S., Zoričić, Z., Filipčić, I., Brečić, P., Seiverth, S., & Sikirić, P. (2022). Pentadecapeptide BPC 157 and the central nervous system. Neural Regeneration Research, 17(3), 482–487. https://doi.org/10.4103/1673-5374.320969
3. Hsieh, M. J., Lee, C. H., Chueh, H. Y., Chang, G. J., Huang, H. Y., Lin, Y., & Pang, J. S. (2020). Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Scientific Reports, 10(1), 17078. https://doi.org/10.1038/s41598-020-74022-y
4. Sikiric, P., Seiwerth, S., Skrtic, A., Staresinic, M., Strbe, S., Vuksic, A., Sikiric, S., Bekic, D., Soldo, D., Grizelj, B., Novosel, L., Beketic Oreskovic, L., Oreskovic, I., Stupnisek, M., Boban Blagaic, A., & Dobric, I. (2025). Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Pleiotropic Effect Controlling and Modulating Angiogenesis and the NO-System. Pharmaceuticals (Basel, Switzerland), 18(6), 928. https://doi.org/10.3390/ph18060928
5. Vukojević, J., Milavić, M., Perović, D., Ilić, S., Čilić, A. Z., Đuran, N., Štrbe, S., Zoričić, Z., Filipčić, I., Brečić, P., Seiverth, S., & Sikirić, P. (2021). Pentadecapeptide BPC 157 and the central nervous system. Neural Regeneration Research, 17(3), 482. https://doi.org/10.4103/1673-5374.320969
6. Huang, T., Zhang, K., Sun, L., Xue, X., Zhang, C., Shu, Z., Mu, N., Gu, J., Zhang, W., Wang, Y., Zhang, Y., & Zhang, W. (2015). Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Design, Development and Therapy, 9, 2485. https://doi.org/10.2147/DDDT.S82030