NAD+

Description

NAD+ (Nicotinamide Adenine Dinucleotide)

NAD+ is a powerful coenzyme naturally present in every cell of the body and plays a vital role in energy metabolism, cellular repair, and longevity. As we age, NAD+ levels decline, leading to fatigue, cognitive slowing, and accelerated aging at the cellular level. Our NAD+ peptide formulation is designed to restore optimal NAD+ levels, rejuvenating cells from within and promoting overall vitality.

Product Summary  NAD+ 500MG

Field	Details
Product Name	NAD+ (Nicotinamide Adenine Dinucleotide)
Category	– Coenzyme found in all living cells, critical for energy metabolism and cellular function.
– Investigational compound with potential anti-aging and longevity benefits.
Molecular Formula	C21H27N7O14P2
Molecular Weight	~663.5 g/mol
Length	2 nucleotides
Form & Purity	Lyophilized powder; ≥98% purity (HPLC-verified, supplier spec).
Storage	Store lyophilized at −20 °C to −80 °C, dry, and protected from light; reconstituted solutions should be stored short-term at 4 °C. Avoid repeated freeze-thaw.
Key Mechanisms	– NAD+ plays a pivotal role in cellular energy production through its involvement in the electron transport chain and mitochondrial function.
	– Activates sirtuins (SIRT1), enzymes that regulate aging and cellular stress resistance.
	– Participates in DNA repair processes and regulates gene expression linked to cell survival.
	– Facilitates oxidative phosphorylation and glycolysis in energy metabolism pathways.
	– Promotes healthy aging by mitigating oxidative stress, inflammation, and cellular dysfunction.
Research Use Cases	– Age-related diseases (neurodegenerative conditions, metabolic disorders, and cardiovascular health).
	– Enhances mitochondrial function and energy production in cells.
	– Potential anti-aging effects by increasing NAD+ levels and activating longevity pathways.
	– Role in enhancing brain function and protecting against neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s).
	– Supports muscle repair and physical performance through improved energy metabolism.
Common AEs	Well tolerated in animal studies and human reports at standard doses. High doses may cause mild flushing, dizziness, or gastrointestinal discomfort.
Compliance	Not FDA/EMA approved for medical use. Available for research use only.
Amino Acid Sequence of NAD+	NAD+ is a coenzyme and does not have a typical amino acid sequence. It consists of a nicotinamide group and an adenine nucleotide bound by a phosphate group.

Mechanism of Action of NAD+

Cellular Energy Production and Metabolism

It is a critical coenzyme in cellular metabolism, particularly in the processes of oxidative phosphorylation and glycolysis, where it helps in the conversion of food into usable energy (ATP). NAD+ enables the transfer of electrons in the mitochondrial electron transport chain, facilitating energy production that supports essential cellular functions.

Activation of Sirtuins and Longevity Pathways

It activates sirtuins (SIRT1), a family of proteins that regulate a variety of biological functions, including aging, inflammation, and stress response. By activating these enzymes, it helps maintain cellular homeostasis, enhances DNA repair, and may extend the lifespan of cells. This makes NAD+ an attractive target in anti-aging and longevity research.

DNA Repair and Maintenance of Genomic Integrity

It is involved in the repair of damaged DNA, primarily through its role in activating the enzyme poly(ADP-ribose) polymerase (PARP). PARP uses NAD+ to assist in DNA repair mechanisms, which is crucial for maintaining genomic integrity and preventing cellular dysfunction associated with aging and diseases.

Reduction of Oxidative Stress and Inflammation

It helps reduce oxidative stress by supporting mitochondrial health and enhancing antioxidant defenses. Through its role in activating sirtuins and other regulatory proteins, NAD+ mitigates the production of reactive oxygen species (ROS) and inflammation, which are contributors to many age-related diseases and degenerative conditions.

Muscle and Brain Health

It is critical for maintaining muscle health by supporting energy metabolism and enhancing the function of mitochondria, which are responsible for producing the energy required for muscle contraction. NAD+ also plays an important role in protecting brain cells from neurodegenerative conditions, such as Alzheimer’s and Parkinson’s, by improving mitochondrial function and supporting cellular repair mechanisms.

Tolerability and Safety Considerations 

It’s supplementation has shown a strong safety profile in both animal and human studies, with minimal adverse effects at typical dosages. However, at high doses, some individuals may experience mild side effects, such as flushing, dizziness, or gastrointestinal discomfort. Further research is needed to understand the long-term effects and optimal dosage for therapeutic use in humans.
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Citations

Imai, S.-I., & Guarente, L. (2014). NAD+ and Sirtuins in Aging and Disease. Trends in Cell Biology, 24(8), 464-471.
Braidy, N., & Alam, S. (2018). NAD+ in Brain Aging and Neurodegenerative Diseases. Current Topics in Medicinal Chemistry, 18(4), 284-294.
Canto, C., & Auwerx, J. (2012). NAD+ as a Therapeutic Target for Age-Related Diseases. Nature Reviews Drug Discovery, 11(10), 596–609.
Yoshino, J., Baur, J. A., & Imai, S.-I. (2018). NAD+ Intermediates: The Biology and Therapeutic Potential of NAD+ Precursors. Cell Metabolism, 27(3), 513-528.

Third Party Verified

500 MG – NDLY809 – 08/23/2025 – SAMPLE A

500 MG – ND601A – 08/23/2025 – SAMPLE B

600 MG – ND601A – 06/23/2025