Description

⚠️ LABORATORY RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL CONSUMPTION
This product is supplied exclusively for in vitro and laboratory research by qualified personnel. It is not approved by the FDA for any clinical, therapeutic, diagnostic, cosmetic, dietary, or veterinary application.

Epitalon

Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed as a synthetic analog of the pineal peptide preparation epithalamin. It is used in cellular-senescence, telomere-biology, and chronobiology research as a tool compound for examining telomerase activity, chromatin organization, and circadian gene expression in cell-culture and preclinical models. Supplied as a lyophilized powder, 11 mg per vial.

Product Specifications

Product Name	Epitalon
CAS Number	307297-39-8
Sequence	Ala-Glu-Asp-Gly
Molecular Formula	C₁₄H₂₂N₄O₉
Molecular Weight	≈390.35 g/mol
Quantity	11 mg per vial
Form	Lyophilized powder
Purity	≥98% (HPLC); see third-party COA
Classification	Synthetic tetrapeptide — cellular-senescence research reagent

Mechanistic Background

Published cell-culture work reports that Epitalon can induce telomerase expression and extend the replicative capacity of human somatic cell lines, supporting its use as a tool for studying telomere maintenance mechanisms.

Research Applications

Epitalon is used in in vitro and preclinical model systems to investigate:

Telomerase (TERT) expression and telomere-length assays in human fibroblast cultures
Replicative-senescence and population-doubling studies
Chromatin condensation and heterochromatin organization
Circadian-rhythm and pineal-gland gene-expression models
Antioxidant enzyme expression and oxidative-stress readouts
Comparative studies with epithalamin extracts

Storage & Handling

Store lyophilized material at −20 °C, protected from light and moisture. Allow the vial to reach room temperature before opening. Following reconstitution in a suitable laboratory buffer, store at 2–8 °C and use within the timeframe established by your laboratory’s stability protocols. Avoid repeated freeze–thaw cycles. Handle in accordance with standard laboratory practice for peptide reagents.

Published Literature

Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590–592.
Anisimov VN, Khavinson VK. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139–149.

Research Use Only Statement

Epitalon is a chemical reagent supplied solely for laboratory research and analytical purposes. It is not a drug, dietary supplement, cosmetic, food additive, or medical device, and it has not been evaluated by the U.S. Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease in humans or animals. Peptide Minds is a research chemical supplier and is not a pharmacy, compounding facility, or medical provider. The purchaser is responsible for ensuring the material is handled by trained personnel in accordance with all applicable laws, regulations, and institutional policies.