Description

⚠️ LABORATORY RESEARCH USE ONLY — NOT FOR HUMAN OR ANIMAL CONSUMPTION
This product is supplied exclusively for in vitro and laboratory research by qualified personnel. It is not approved by the FDA for any clinical, therapeutic, diagnostic, cosmetic, dietary, or veterinary application.

Selank

Selank is a synthetic heptapeptide derived from the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg) extended with a Pro-Gly-Pro C-terminal sequence that enhances proteolytic stability. It is used in neuroscience and immunology research as a tool compound for GABAergic modulation, neurotrophin expression, and cytokine-signaling studies in cellular and preclinical models. Supplied as a lyophilized powder, 10 mg per vial.

Product Specifications

Product Name	Selank
CAS Number	129954-34-3
Sequence	Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Formula	C₃₃H₅₇N₁₁O₉
Molecular Weight	≈751.9 g/mol
Quantity	10 mg per vial
Form	Lyophilized powder
Purity	≥98% (HPLC); see third-party COA
Classification	Synthetic tuftsin-analog peptide — research reagent

Mechanistic Background

Preclinical work reports that Selank influences GABAergic transmission, modulates expression of neurotrophic factors, and alters cytokine expression profiles, providing a multi-pathway tool for neuroimmune research.

Research Applications

Selank is used in in vitro and preclinical model systems to investigate:

GABA-A receptor modulation and allosteric-binding assays
BDNF expression and neurotrophic signaling in neuronal cultures
Cytokine expression (IL-1β, IL-6, TNF-α, TGF-β1) in immune-cell models
Serotonin and enkephalin metabolism readouts
Gene-expression profiling in preclinical CNS models
Comparative studies with tuftsin and related Pro-Gly-Pro peptides

Storage & Handling

Store lyophilized material at −20 °C, protected from light and moisture. Allow the vial to reach room temperature before opening. Following reconstitution in a suitable laboratory buffer, store at 2–8 °C and use within the timeframe established by your laboratory’s stability protocols. Avoid repeated freeze–thaw cycles. Handle in accordance with standard laboratory practice for peptide reagents.

Published Literature

Kolomin T, Shadrina M, Slominsky P, Limborska S, Myasoedov N. A new generation of drugs: synthetic peptides based on natural regulatory peptides. Neurosci Med. 2013;4:223–252.
Volkova A, Shadrina M, Kolomin T, et al. Selank administration affects the expression of some genes involved in GABAergic neurotransmission. Front Pharmacol. 2016;7:31.

Research Use Only Statement

Selank is a chemical reagent supplied solely for laboratory research and analytical purposes. It is not a drug, dietary supplement, cosmetic, food additive, or medical device, and it has not been evaluated by the U.S. Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease in humans or animals. Peptide Minds is a research chemical supplier and is not a pharmacy, compounding facility, or medical provider. The purchaser is responsible for ensuring the material is handled by trained personnel in accordance with all applicable laws, regulations, and institutional policies.