PT-141 (Bremelanotide): Premium Research-Grade Peptide

Description

PT-141 (Bremelanotide) is a synthetically engineered cyclic heptapeptide derived from α-melanocyte-stimulating hormone (α-MSH), designed for selective investigation of melanocortin receptor pathways, particularly MC3R and MC4R. Recognized for its unique central nervous system activity profile, PT-141 has become an important research tool in neuroendocrine biology and receptor signaling studies.

At Peptide Minds, PT-141 is produced to uncompromising quality standards under controlled laboratory conditions and verified through independent third-party analytical testing. Each batch is accompanied by a full Certificate of Analysis (COA), ensuring structural integrity, purity, and reproducibility for advanced scientific research.

This compound is supplied strictly for laboratory research and in vitro studies only. It is not intended for human or veterinary use.

Molecular Profile & Specifications

PT-141 is a structurally optimized cyclic peptide featuring strategic amino acid substitutions that enhance receptor affinity and metabolic stability in experimental systems.

Specification	Details
Peptide Name	PT-141 (Bremelanotide)
Peptide Class	Synthetic melanocortin receptor agonist
Sequence	Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Molecular Formula	C₅₀H₆₈N₁₄O₁₀
Molecular Weight	~1025.2 Da
Structure	Cyclic heptapeptide (lactam bridge)
Purity	≥95% (HPLC-verified)
Form	Lyophilized solid
Storage	20–25°C, protected from light; do not freeze

 

Scientific Foundation

The melanocortin system is a highly conserved neurochemical network involved in central signaling pathways governing autonomic, endocrine, and motivational regulation. PT-141 functions as a potent agonist within this system, demonstrating activity at melanocortin receptor subtypes expressed in key hypothalamic and limbic regions.

Unlike peripherally acting compounds, PT-141 is characterized by its central mechanism of action, making it a valuable tool for investigating neuroreceptor signaling, neurochemical integration, and central autonomic regulation in controlled laboratory models.

Mechanism of Action

PT-141 binds to melanocortin receptors MC3R and MC4R, initiating intracellular signaling cascades primarily mediated through cyclic AMP (cAMP) pathways. This receptor activation modulates downstream neurotransmitter networks, including dopaminergic and serotonergic systems, which are extensively studied in neurobehavioral research.

Preclinical models suggest that melanocortin receptor activation may influence hypothalamic circuits and mesolimbic pathways, contributing to measurable changes in central nervous system signaling dynamics. These findings continue to position PT-141 as a valuable compound in receptor pharmacology and neuroendocrine research.

Research Applications

PT-141 is utilized in advanced laboratory environments investigating:

• Melanocortin receptor pharmacodynamics (MC3R / MC4R)
• Central nervous system signaling pathways
• Neuroendocrine regulation models
• Dopaminergic and serotonergic interaction studies
• Hypothalamic receptor mapping
• Behavioral neurobiology (preclinical models only)
• Autonomic nervous system modulation research
• Ligand-receptor binding assays and signaling studies

Its unique pharmacological profile continues to support expanded exploration of central melanocortin pathways in modern neuroscience research.

 

Quality Assurance & Manufacturing Excellence

Every batch of PT-141 is manufactured under stringent quality systems designed to meet the expectations of advanced research institutions.

Peptide Minds ensures:

• Independent third-party HPLC verification
• Mass spectrometry confirmation of molecular identity
• Full Certificate of Analysis (COA) per batch
• GMP-aligned manufacturing protocols
• Controlled environmental synthesis conditions
• Secure, research-grade packaging and handling

This commitment to analytical precision ensures consistency, reliability, and scientific integrity across all research applications.

Storage & Stability

To preserve structural stability and analytical performance, PT-141 should be stored under the following conditions:

• Maintain at 20–25°C (room temperature)
• Protect from direct light exposure
• Avoid freezing or repeated thermal cycling
• Store in original sealed packaging until use

Proper handling ensures optimal peptide integrity throughout the research lifecycle.

The Peptide Minds Standard

At Peptide Minds, we are committed to delivering research compounds that meet the highest standards of purity, consistency, and scientific reliability.

Researchers choose our PT-141 for:

• Precision-manufactured peptide synthesis
• Verified analytical documentation (COA included)
• Batch-to-batch consistency
• Secure, discreet, and stable shipping
• Premium research support infrastructure

Explore complementary compounds including MOTS-C, NAD+, BPC-157, and other advanced peptides available in our research catalog.

Citations

• Zhang, H., Chen, L. N., Yang, D., Mao, C., Shen, Q., Feng, W., Shen, D. D., Dai, A., Xie, S., Zhou, Y., Qin, J., Sun, J. P., Scharf, D. H., Hou, T., Zhou, T., Wang, M. W., & Zhang, Y. (2021). Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell research, 31(11), 1163–1175. https://doi.org/10.1038/s41422-021-00552-3
• Molinoff, P. B., Shadiack, A. M., Earle, D., Diamond, L. E., & Quon, C. Y. (2003). PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Annals of the New York Academy of Sciences, 994, 96–102. https://doi.org/10.1111/j.1749-6632.2003.tb03167.x
• King, S. H., Mayorov, A. V., Balse-Srinivasan, P., Hruby, V. J., Vanderah, T. W., & Wessells, H. (2007). Melanocortin Receptors, Melanotropic Peptides, and Penile Erection. Current Topics in Medicinal Chemistry, 7(11), 1098. https://pmc.ncbi.nlm.nih.gov/articles/PMC2694735/
• Kingsberg, S. A., Clayton, A. H., Portman, D., Williams, L. A., Krop, J., Jordan, R., Lucas, J., & Simon, J. A. (2019). PT-141 for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials. Obstetrics and Gynecology, 134(5), 899–908. https://doi.org/10.1097/AOG.0000000000003500

Explore our complete catalog of high-purity, third-party-tested research compounds on our main shop page for all your laboratory needs.

Third Party Verified

11 MG – PT0108L – 01/23/2025

8 MG – NCKOLT5 – 09/25/2024

Frequently Asked Questions

What is PT-141 used for in research settings?

PT-141 is studied as a melanocortin receptor agonist in neuroendocrine, receptor signaling, and central nervous system research models.

Which receptors does PT-141 interact with?

It primarily targets MC3R and MC4R melanocortin receptors involved in central signaling pathways.

How should PT-141 be stored?

Store at controlled room temperature (20–25°C), protected from light, and avoid freezing.

Does PT-141 include COA documentation?

Yes. Every batch includes a full Certificate of Analysis verifying purity and identity.

Is PT-141 approved for human use?

No. PT-141 supplied here is strictly for laboratory research purposes only.