TB-500

What is TB-500 (Thymosin Beta-4)? A Key Regenerative Peptide

TB-500, also known as Thymosin Beta-4, is a 43 amino acid peptide naturally occurring in human and animal tissues. This TB-500 peptide belongs to the thymosin family, a group of 16 related molecules known for their role in tissue repair and regeneration. It is highly conserved across species and plays a crucial role in cell differentiation, migration, and actin sequestration. TB-500 promotes wound healing, blood vessel growth, and anti-inflammatory effects, making it a vital component in regenerative medicine. Additionally, it interacts with actin to support cell structure and mobility, contributing to its potential in anti-aging research and peptide therapy.

TB-500 (Thymosin Beta-4) Structure: Molecular Details and Sequence

Understanding the structure of TB-500 is essential for researchers exploring regenerative peptides and their applications in tissue repair and anti-aging therapy. Below are the key structural details of this TB-500 peptide (Thymosin Beta-4):

• Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
• Molecular Formula: C212H350N56O78S
• Molecular Weight: 4963.49 g/mol
• PubChem CID: 16132341
• CAS Number: 77591-33-4

The TB-500 structure enables its interaction with actin, supporting cell migration and tissue regeneration, which are critical for its role in wound healing and regenerative medicine research.

Effects of TB-500 (Thymosin Beta-4) Demonstrated in Recent Studies

Recent studies highlight the diverse therapeutic effects of TB-500 (Thymosin Beta-4) in regenerative medicine and anti-aging research. Key findings include:

• Promotes Endothelial and Blood Vessel Growth: TB-500 enhances angiogenesis and endothelial cell differentiation, supporting the growth of new blood vessels in dermal tissues for improved wound healing.
• Enhances Keratinocyte Migration: It facilitates keratinocyte migration, aiding in skin repair and tissue regeneration.
• Supports Collagen Deposition: TB-500 promotes collagen deposition, strengthening tissue structure during healing processes.
• Reduces Inflammation in Joints: Its anti-inflammatory effects help decrease inflammation in joints, supporting joint health and mobility.
• Improves Muscle Growth and Strength: TB-500 increases muscle growth and endurance, while reducing muscle spasms and improving muscle tone.
• Enhances Cell Communication: It improves the exchange of substances between cells, promoting tissue repair and regeneration.
• Supports Tissue Repair: TB-500 stretches connective tissue and maintains flexibility, aiding in the repair of damaged tissues.
• Prevents Adhesions and Fibrosis: It helps prevent the formation of adhesions and fibrous bands in muscles, tendons, and ligaments, supporting overall tissue health.

These findings underscore TB-500’s potential in peptide therapy for applications in wound healing, anti-inflammatory treatments, and muscle recovery.