Selank Overview: Anxiety Relief and Beyond
Selank is a synthetic peptide developed in Russia, renowned for its anxiolytic and nootropic properties. An analog of the natural tetrapeptide tuftsin, Selank enhances brain-derived neurotrophic factor (BDNF) levels, improving memory and learning while reducing anxiety. Its extended structure increases metabolic stability, making it a promising treatment for generalized anxiety disorder. Selank also modulates immune responses and enkephalin degradation, offering stress relief and cognitive benefits without the dependence risks of traditional anxiolytics.
Key Benefits: Anxiety reduction, cognitive enhancement, immune modulation.
What is Selank? A Peptide for Mind and Mood
Selank is a synthetic heptapeptide derived from tuftsin, designed to regulate GABA neurotransmission and enhance cognitive function. Developed at the Institute of Molecular Genetics in Russia, it influences gene expression related to memory and stress response. Unlike benzodiazepines, Selank offers anxiety relief and memory improvement without sedation or withdrawal risks, making it a versatile nootropic and therapeutic agent.
Applications: Anxiety management, memory support, stress relief.
Selank Structure: Chemical Insights
Selank’s molecular design drives its efficacy as an anxiolytic and cognitive enhancer:
- Amino Acid Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
- Molecular Formula: C33H57N11O9
- Molecular Weight: 751.87 g/mol
- Structure Type: Linear heptapeptide
- Solubility: Water-soluble
- PubChem CID: 117583997
- Synonyms: Selanc
With four additional amino acids compared to tuftsin, Selank boasts improved stability and half-life, ideal for intranasal administration.
Selank Research: Scientific Findings
Selank’s benefits are backed by robust research. Below are key studies with verified links:
- GABA Neurotransmission: Volkova et al. (2016) found Selank alters 45 GABA-related genes, reducing anxiety. Front. Pharmacol., 2016
- Anxiety and Stress: Kasian et al. (2017) showed Selank enhances diazepam’s anxiolytic effects in rats. Behav. Neurol., 2017
- Enkephalin Mechanism: Zozulya et al. (2001) identified Selank’s inhibition of enkephalin-degrading enzymes. Bull. Exp. Biol. Med., 2001
- Behavioral Effects: Godlevsky et al. (not fully cited) explored Selank’s impact on emotional stress in mice. Bull. Exp. Biol. Med., 2003
- Immunity: Uchakina et al. (2008) reported Selank’s immunomodulatory effects in anxiety disorders. Zh. Nevrol. Psikhiatr., 2008
- Anxiolytic Efficacy: Zozulya et al. (2008) confirmed Selank’s role in treating anxiety and neurasthenia. Zh. Nevrol. Psikhiatr., 2008
- Inflammation: Kolomin et al. (2011) found Selank suppresses inflammation-related genes in mice. Regul. Pept., 2011
- BDNF Expression: Agapova et al. (2009) showed Selank boosts BDNF in the hippocampus. Mol. Genet. Mikrobiol. Virusol., 2009
- Learning Optimization: Semenova et al. (2016) demonstrated Selank’s memory-enhancing effects in rats. Eksp. Klin. Farmakol., 2016
- Catecholamine System: Kolomin et al. (2013) linked Selank to cognitive recovery post-damage. Bull. Exp. Biol. Med., 2013
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